COVID-19 Round 17 - get vaxed, get waxed, get ready to climax

Did the Greeks try to tell you then invented Covid? If not then I’m not sure they’re really Greek.

Could be a spin off, Gladys and Jeanette going toe to toe as GG and State Governor, perhaps Nicola as SA Governor to referee ?
When does term of current GG expire?

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lmao

covid and it’s vaccinations have got to be the most studied thing in human history, apart from maybe the fruit fly breeding thing everyone did in year 8 science

We just got a new governor but it’s not Nicola. Her name is Frances. Could still fit the gig.

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Ex DFAT and a pearl wearer IIRC

Correct.

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How long before governments and businesses give up on this mandatory vaccine policy because it’s too hard, and the minority of good people lost to them will go work elsewhere? Anti vax crazies I don’t feel sympathy for, but there’s a small group of people who are hesitating for their own reasons. I agree they shouldn’t wait or refuse, but that’s their reality. It’s all so divisive as well, i feel like society is more hostile towards each other than ever.

Is Gladys looking to get a gig at cross town rival The Bold and the Beautiful?
Let’s ask @Stallion if he’s heard any gossip from his girlfriends at the Salon today.

It’s almost like you’ve ignored the hundreds of times he has said “The best vaccine is the one you can get today”. And guess what? He just did it again. He promoted the vaccine you can get today, without even booking.

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jui

People with substance use disorders may be at higher risk for SARS-CoV-2 breakthrough infections

Co-occurring health disorders appear to contribute to increased risk, NIH study suggests

NIH/National Institute on Drug Abuse

An analysis of electronic health records of nearly 580,000 fully vaccinated people in the United States found that the risk of SARS-CoV-2 breakthrough infection among vaccinated patients with substance use disorders was low overall, but higher than the risk among vaccinated people without substance use disorders. The study was published today in World Psychiatry and led by researchers at the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health, and Case Western Reserve University in Cleveland, Ohio.

The study also found that co-occurring health conditions and adverse socioeconomic determinants of health, which are more common in people with substance use disorders, appear to be largely responsible for the increased risk of SARS-CoV-2 breakthrough infections. People with substance use disorders—such as alcohol, cannabis, cocaine, opioid, and tobacco use disorders— also had elevated rates of severe outcomes, including hospitalization and death, following breakthrough infections.

“First and foremost, vaccination is highly effective for people with substance use disorders, and the overall risk of COVID-19 among vaccinated people with substance use disorders is very low.” said NIDA Director Nora D. Volkow, M.D., and one of the lead authors on the study. "We must continue to encourage and facilitate COVID-19 vaccination among people with substance use disorders, while also acknowledging that even after vaccination, this group is at an increased risk and should continue to take protective measures against COVID-19.”

Analyses conducted in the early stages of the pandemic found that people with substance use disorders were at increased risk of SARS-CoV-2 infection, and were more likely to have severe disease requiring hospitalization or resulting in death. This was particularly true for Black people with a substance use disorder. Since then, vaccines became widely available for people ages 12 and older that greatly reduce the risk of COVID-19 and severe disease.

However, clinical trials evaluating the effectiveness of these vaccines did not specifically include people with substance use disorders. Because many people with substance use disorders are immunocompromised due to drug use and co-occurring diseases, researchers hypothesized that this population might be at increased risk of breakthrough infections after getting vaccinated.

To investigate these questions, researchers analyzed electronic health records from nearly 580,000 people in the United States with and without substance use disorders who were fully vaccinated against COVID-19 between December 1, 2020, and August 14, 2021, and who had not been infected with SARS-CoV-2 before the vaccination. The status of infection was based on the ICD-10 di­agnosis code of COVID-19 or lab-test confirmed pres­ence of SARS-CoV-2 and related RNA.

They determined the proportion of people in each group who contracted SARS-CoV-2 at least 14 days after their final vaccination. This analysis was repeated after matching patients with and without substance use disorders for demographic characteristics; socioeconomic factors that influence health, such as housing or employment instability; and lifetime physical illnesses, such as high blood pressure, heart disease, obesity, or diabetes. The team also examined if fully vaccinated people with breakthrough infections had a different risk for hospitalization and death compared with matched people without breakthrough infections.

The researchers found that the risk of breakthrough infections was significantly higher in people with substance use disorders than in those without: 7% of vaccinated people with substance use disorders had a breakthrough infection during the study, compared with 3.6% of vaccinated people without substance use disorders. The risk of breakthrough infection varied slightly among people with different substance use disorders, ranging from 6.8% for people with tobacco use disorder to 7.8% for those with cannabis use disorder.

The study suggests that the increased risk of breakthrough infections in people with substance use disorders was primarily due to co-occurring diseases and adverse socioeconomic characteristics. When these factors were controlled for, people with most substance use disorders no longer had elevated rates of breakthrough infections. The only exception were people with cannabis use disorder, who still were 55% more likely to experience breakthrough infections as people without substance use disorders, even though patients with cannabis use disorder tended to be younger and had fewer co-occurring health conditions than those with other substance use disorders. The authors hypothesized that factors such as adverse effects of cannabis on lung and immune function may have contributed to the higher risk for breakthrough infection in this group.

In addition, breakthrough infections were found to greatly increase the risk of severe outcomes, including hospitalization and death, regardless of the presence of substance use disorders. Among the people with substance use disorders, 22.5% of those with a breakthrough infection required hospitalization, and 1.7% died during the study period, compared with 1.6% and 0.5%, respectively, among people with substance use disorders but no breakthrough infection. Additionally, the risk of severe outcomes after breakthrough infection was higher in patients with substance use disorders than in those without substance use disorders.

“From previous studies, we knew that people with substance use disorders may be particularly vulnerable to COVID-19 and severe related outcomes. These results emphasize that, while the vaccine is essential and effective, some of these same risk factors still apply to breakthrough infections,” said Rong Xu, Ph.D., professor in the Center for Artificial Intelligence in Drug Discovery at Case Western Reserve University. “It is important to continuously evaluate the effectiveness of COVID-19 vaccines and the long-term effects of COVID-19, especially among people with substance use disorders.”

Reference: L ■■■■, QQ ■■■■, PB Davis, et al. Increased risk for COVID-19 breakthrough infection in fully vaccinated patients with substance use disorders in the United States between December 2020 and August 2021. World Psychiatry. DOI: 10.1002/wps.20921 (2021).

About the National Institute on Drug Abuse (NIDA): NIDA is a component of the National Institutes of Health, U.S. Department of Health and Human Services. NIDA supports most of the world’s research on the health aspects of drug use and addiction. The Institute carries out a large variety of programs to inform policy, improve practice, and advance addiction science. For more information about NIDA and its programs, visit www.nida.nih.gov.

About the National Institutes of Health (NIH) : NIH, the nation’s medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.

NIH…Turning Discovery Into Health®

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It didn’t come from the Premier of Messaging though.

Well duh, people with substance abuse problems are less healthy than the general population.

Dumb message. Will only encourage people to ■■■■■ and moan about ‘not being able to get the best vaccine’ etc.

Not only do you have to bend rules to get a third dose right now, but I have never seen a suggestion anywhere that it would be particularly beneficial 3 weeks after being double vaccinated. Perhaps it would, but the suggestions are usually around 5 months or more after being fully vaccinated.

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I wonder how far the authorities in each country will go to implement and enforce mandatory vaccination - When you consider that international travel will mandate vaccinations, then eventually some will be vaccinated by default.

Third dose for the elderly and immune compromised appears to be based on lower efficacy of vax for that group

  • as compared to longevity of efficacy in general population?

Hence splitting of additional doses into third and booster use?

Have there been suggestions of handing out 3 doses of, say, Pfizer over a 6 week period? (3 weeks between doses)

Caffeine use disorder would have to be higher?

I’m holding a cup, I’m immune.

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It’s done now to a certain extent when we have herd immunity - the grant of some visas is conditional on vax to the Australian standard
And in the case of yellow fever, mandatory quarantine for anyone returning unvaxed from a declared yellow fever zone.
There are adaptable international WHO precedents and recent statements on the development of an Australian digital vax passport refer to ICAO standards.